Needle-less® Serum
Needle-less® Serum
Experience smoother, firmer, and deeply hydrated skin—no injections required. This multitasking serum combines our proprietary CeraPep™ Technology with targeted peptides, ceramides, and sodium hyaluronate to visibly refine texture, calm visible redness, and support a healthy-looking skin barrier. It’s a simplified solution that helps skin look more radiant, balanced, and youthful.
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About this item
- Potent Blend of Ingredients: The best-selling DRMTLGY Needle-less serum features an advanced formula combining Niacinamide, Hyaluronic Acid, Peptides & Ceramides to help with signs of aging.
- Targets Appearance of Fine Lines: Powerful anti-aging active ingredients help to firm the skin as well as reduce fine lines and wrinkles resulting in firmer and brighter-looking skin.
- Proven Results: Based on a 6-week independent consumer panel, 94% said that their skin felt smoother & looked healthier. 91% said they had firmer feeling skin.
- Safe for All Skin Types: The wrinkle serum is gentle on the skin, non-greasy, non-comedogenic and suitable for any skin care routine.
- Clean Formula Made in the USA: Our hyaluronic acid serum for face is cruelty free and was formulated with you in mind right here in the USA!
4 Reasons Everyone Loves Needle-less® Serum
Dramatic Anti-aging Results You Can See After 6 Weeks
94%
saw healthier-looking skin
91%
had firmer-feeling skin
94%
said skin felt smoother
Based an a six-week independent consumer panel
Before and After 60 Days Of Use
When used as directed. Unedited and not retouched. Results may vary.
Full Description
As skin matures, it can begin to look less firm and smooth, with more visible lines and uneven texture. Daily exposure to environmental stressors and overuse of harsh products can also weaken the skin’s protective barrier, making it appear more prone to dryness and visible redness. Needle-less® Serum was created to help address these visible signs of aging and restore a look of balance, comfort, and vitality.
Our proprietary CeraPep™ Technology combines three skin-identical ceramides with a targeted peptide blend to replenish essential lipids and support the look of a stronger, more resilient skin barrier. This dual-action formula helps improve the appearance of firmness, visibly smooth texture, and deliver lasting hydration. To further calm and refine the complexion, we included niacinamide, a form of vitamin B3 known to help reduce visible redness, minimize the look of pores, and promote an even-looking tone.
Deep hydration is essential for maintaining a youthful-looking complexion. Sodium hyaluronate, a form of hyaluronic acid with a smaller molecular weight, attracts and retains moisture to help visibly plump and smooth the look of fine lines. Meanwhile, pea extract and copper peptides help improve the appearance of elasticity and radiance for a more revitalized look.
Whether you’re looking to extend the benefits of your professional treatments or prefer a non-invasive option, Needle-less® Serum seamlessly fits into any skincare routine.
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CRUELTY FREE
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DERMATOLOGIST RECOMMENDED
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SULFATE FREE
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PARABEN FREE
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GLUTEN FREE
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FRAGRANCE FREE
Directions
Apply 4 to 5 drops onto fingers and smooth over a slightly damp face. Avoid getting too close to the eyes.
Allow to absorb before applying additional products.
Can be used twice a day or as directed by a physician.
How to Layer Your DRMTLGY Products
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MORNING
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NIGHT
Ingredients
Ingredient Highlights
Niacinamide (Vitamin B3), Hyaluronic Acid (Sodium Hyaluronate), Methyl Glucoside Phosphate Proline Lysine Copper Complex, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Ceramide EOP, Ceramide NP, Palmitoyl Tripeptide-5, Ceramide AP, Sodium Chondroitin Sulfate, Glycosaminoglycans, Pea Extract, Glucosamine HCI, Panthenol (Provitamin B5), Bambusa Vulgaris Leaf/Stem Extract
All Ingredients
Water, Glycerin, Sodium Chondroitin Sulfate, Sodium Hyaluronate, Pisum Sativum (Pea) Extract, Bambusa Vulgaris Leaf/Stem Extract, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Ceramide EOP, Glucosamine HCl, Glycosaminoglycans, Ceramide NP, Palmitoyl Tripeptide-5, Ceramide AP, Phytosphingosine, Cholesterol, Niacinamide, Sodium Lauroyl Lactylate, Methylglucoside Phosphate, Copper Lysinate/Prolinate, Panthenol, Tocopheryl Acetate, Phenoxyethanol, Polysorbate 20, Ethylhexylglycerin, Disodium EDTA, Butylene Glycol, Carbomer, Xanthan Gum
DRMTLGY is dedicated to maintaining the accuracy of the ingredient lists on this website. However, because ingredients are subject to change, we cannot guarantee that these lists are error-free. For an accurate listing of ingredients in each product, please refer to your product packaging.
Meet our Board of Dermatologists
Our board of renowned dermatologists brings together years of expertise in skincare, research, and medical innovation. With a shared commitment to advancing dermatological science, they play a crucial role in developing and refining our formulations. Get to know the experts shaping the future of skincare.
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Dr. Lejla Cirkic
MD, FAAD
As a Dermatology Medical Director, she oversees the design and execution of clinical trials that push the boundaries of dermatologic science and patient centered care. She’s especially known for making complex skin topics both accessible and entertaining through her viral social media presence, where she educates millions with a signature blend of expertise, humor, and straightforward advice. Dr. Cirkic is committed to reshaping how people learn about and engage with their skin, online and in clinic.
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Dr. Jarett Casale
MD, FAAD
Dr. Jarett Casale is a board-certified dermatologist and fellowship-trained Mohs surgeon specializing in skin cancer treatment, with extensive publications and presentations in the field. He is dedicated to medical education and global health, contributing through lectures, social media, and medical relief missions in Guatemala and Haiti. Outside of medicine, he enjoys cycling, hiking, weightlifting, painting, and glass lampworking.
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Dr. Ariana Eginli
MD, FAAD
Dr. Ariana Eginli is a practicing board-certified Dermatologist in Southern California, who is skilled in treating patients with complex dermatologic conditions, cosmetics, and hair and scalp disorders. She strives to educate her patients and make them feel comfortable in their own skin.
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Dr. Brittany Oliver
MD, FAAD
Dr. Oliver is a board-certified dermatologist practicing in the Kansas City metro area. Recognized as a Castle Connolly Rising Star in 2023 and 2024, she is passionate about delivering individualized care to diverse patients of all ages and backgrounds.
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Dr. Marisa Garshick
MD, FAAD
Selected as New York SuperDoctors in 2021, she has a passion for being able to improve patient’s quality of life and loves to help her patients look and feel their best. She previously worked for the Dr. Oz Show and has been featured in many publications including Woman’s Health and Elle.
What Does Vitamin C Do for Your Skin? Why It’s a Must-Have in Your Routine
Key Takeaways:
- Shields Skin From Sun Damage and Oxidative Stress: Vitamin C in skincare acts as a potent antioxidant, defending against UV damage and oxidative stress while supporting a more resilient complexion, particularly beneficial for women experiencing hormonal changes.
- Lightens Dark Spots for Radiant Glow: Consistent use of vitamin C can help lighten dark spots and hyperpigmentation by inhibiting melanin production, contributing to a more even skin tone and radiant complexion.
- Boosts Collagen, Smooths Wrinkles, and Improves Texture: Vitamin C can enhance collagen production, smoothing wrinkles and improving skin texture, making it a valuable addition to mature skincare routines, especially during perimenopause and menopause.
Standing in front of shelves of serums can feel overwhelming. Among them, one ingredient consistently rises to the top for clinical credibility and visible results: Vitamin C. This powerhouse antioxidant has earned its reputation in dermatology, praised for brightening, collagen support, and protecting skin from environmental stress. What does vitamin C do for your skin, and why is it so valuable during perimenopause and postmenopause, when dryness, dullness, and sensitivity become everyday concerns?
At DRMTLGY, we believe Vitamin C deserves its place at the center of skincare routines. With scientific research guiding our formulations, we’ve seen how it can transform skin by softening wrinkles and brightening your complexion. In this article, we’ll explore what does vitamin C do for your skin in detail, highlight vitamin C serum benefits, and answer common questions like, “Does vitamin C help acne?” By the end, you’ll have a clear, trustworthy guide to why Vitamin C belongs in daily care, from restoring radiance to defending skin against future damage.
Shields Skin From Sun Damage
Daily sun exposure is one of the leading drivers of premature skin changes, from dark spots to fine lines and uneven tone. When ultraviolet (UV) rays penetrate the skin, they generate free radicals, harmful molecules that disrupt healthy cell growth.
When applied topically, Vitamin C functions as a powerful antioxidant. Research shows that consistent use of vitamin C skincare can neutralize free radicals before they cause lasting harm. While it doesn’t replace sunscreen, pairing a broad-spectrum SPF with a vitamin C serum creates a stronger shield against environmental damage. This combination can contribute to long-term skin resilience and healthier texture.
For women in perimenopause or postmenopause, skin sensitivity to sunlight often increases. Hormonal shifts may leave complexions more vulnerable to dryness, dullness, or flare-ups like adult acne. Adding Vitamin C to your daily routine may help reinforce the skin’s barrier, lighten the appearance of sun-related dark spots, and maintain vitality. In this way, Vitamin C plays a dual role: protecting against future damage while enhancing radiance already present in the skin.
OUR STORY
Science-Backed Skincare, Simplified.
DRMTLGY was born of the belief that evidence-based, dermatological skincare should be available to everyone. With a rich, 20-year history in skincare manufacturing and deep roots in the dermatology community, we saw first-hand that skincare companies are overcharging their customers for medical grade ingredients.
This is what Medical Grade means to us:
We partnered with world-class chemists and expert dermatologists to create proprietary formulas with the best of ingredients. We committed to combining the art of formulation with the science of skin because we believe everyone should have access to safe, effective skincare—without unnecessary markups.
After more than a decade of extensive research, clinical testing, and physician feedback, we’re proud to offer a diverse selection of more than 40 clinically effective products for all skin types, tones, concerns, and ages. To date, we’ve transformed over 4 million skincare routines—and we’re just getting started.
OUR 4 CORE
Frequently Asked Questions
Is Needle-less Serum safe for sensitive skin?
Is Needle-less Serum safe for sensitive skin?
Yes, this serum is suitable for all skin types, including sensitive and oily skin. It's a perfect serum for those wanting anti-aging results without a heavy feel or irritation.
Can I use it with retinoids?
Can I use it with retinoids?
Yes, this serum pairs perfectly with retinoids in your evening routine. Apply serum first, allow to absorb fully before applying retinoid.
When will I see results?
When will I see results?
Consistency and patience is key. You will start to notice results in a few weeks but we recommend using 2X a day for 6-8 weeks to see real results.
How should I incorporate this into my routine?
How should I incorporate this into my routine?
Apply to slightly damp skin as the first step in your AM & PM routine after cleansing and toning.
Can I use Needle-less Serum if I get injectables?
Can I use Needle-less Serum if I get injectables?
Absolutely! This serum will prolong results of your injectables. If you do not get injectables, this makes for a perfect non-invasive alternative option.